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ELL2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501987650
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50-198-7650 100 μL
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Catalog No. 50-198-7650 Supplier Bioss Supplier No. BS6993R
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Description

Rabbit Polyclonal Antibody

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.

Specifications

Antigen ELL2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene ELL2
Gene Accession No. O00472
Gene Alias BOS_8497; cb244; eleven-nineteen lysine-rich leukemia gene 2; ELL2; ELL-related RNA polymerase II, elongation factor; elongation factor for RNA polymerase II 2; elongation factor RNA for polymerase II 2; elongation factor RNA polymerase II 2; elongation factor, RNA polymerase II, 2; fb78f03; im:3814960; RNA polymerase II elongation factor ELL2; sb:cb244; wu:fb78f03; wu:fb78f03 protein
Gene Symbols ELL2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human ELL2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 22936
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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