Invitrogen™ ELL3 Polyclonal Antibody

Catalog No.	Quantity
PIPA556015	100 μL

Catalog No. PIPA556015 Supplier Invitrogen™ Supplier No. PA556015

Description

Rabbit Polyclonal Antibody

Immunogen sequence: HRGYLRLPGP GWSCLFSFIV SQCCQEGAGG SLDLVCQRFL RSGPNSLHCL GSLRERLIIW AAMDSIPAPS SVQGHNLTED ARHPESWQNT GGYSEGDAVS QPQMALEEVS VSDPLASN Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 71%.

Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968).

Specifications

• Antigen: ELL3
• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: ELL3
• Gene Accession No.: Q9HB65
• Gene Alias: A930015D22Rik; Ell3; elongation factor for RNA polymerase II 3; elongation factor RNA polymerase II-like 3; RNA polymerase II elongation factor ELL3; similar to elongation factor RNA polymerase II-like 3
• Gene Symbols: ELL3
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human ELL3. Recombinant protein control fragment (Product #RP-89344).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 80237
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG