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ELL3 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA570583
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PIPA570583 100 μL
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Catalog No. PIPA570583 Supplier Thermo Scientific Supplier No. PA570583

Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 86%; Dog: 86%; Horse: 86%; Human: 100%; Mouse: 86%; Pig: 79%; Rabbit: 86%; Rat: 86%

Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT). Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968).
TRUSTED_SUSTAINABILITY

Specifications

Antigen ELL3
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene ELL3
Gene Accession No. Q80VR2
Gene Alias A930015D22Rik; Ell3; elongation factor for RNA polymerase II 3; elongation factor RNA polymerase II-like 3; RNA polymerase II elongation factor ELL3; similar to elongation factor RNA polymerase II-like 3
Gene Symbols ELL3
Host Species Rabbit
Immunogen synthetic peptide directed towards the C-terminal region of mouse ELL3
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 269344
Target Species Mouse
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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