Tocris Bioscience™ EM 163

Catalog No. 70-101-0

Supplier: Tocris Bioscience™ 7010/10

Description

TIR-TIR interaction inhibitor

EM 163 is a TIR-TIR interaction inhibitor, that is a TIR (Toll/ interleukin-1 receptor) domain peptidomimetic of MyD88 protein. EM 163 targets TIR domains in IL-1 receptors blocking the interaction with MyD88. EM 163 inhibits staphylococcal enterotoxin B (SEB)-induced inflammatory cytokine production in vivo. EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocks the activation of p38 and the inhibitory effects of IL-1β on protein synthesis triggered by chemically-induced long-term potentiation (LTP).

Greener Choice Claims

• Environmental benefits include:
• Ozone-Safe or Safe for the Ozone Layer

Specifications

• Chemical Name or Material: 1-Methyl-2,5-bis[[[(1 S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl](3-phenylpropyl)amino]carbonyl]pyridinium iodide
• CAS: 1206480-93-4
• Quantity: 10 mg
• Target: Cytokine Compounds
• Molecular Formula: C₄₄H₆₀IN₅O₄
• Purity: 98%