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Tocris Bioscience™ EM 163
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Catalog No. 701010
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10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

TIR-TIR interaction inhibitor

EM 163 is a TIR-TIR interaction inhibitor, that is a TIR (Toll/ interleukin-1 receptor) domain peptidomimetic of MyD88 protein. EM 163 targets TIR domains in IL-1 receptors blocking the interaction with MyD88. EM 163 inhibits staphylococcal enterotoxin B (SEB)-induced inflammatory cytokine production in vivo. EM 163 protects mice from SEB shock-induced death. In rat hippocampal neurons in vitro, EM 163 blocks the activation of p38 and the inhibitory effects of IL-1β on protein synthesis triggered by chemically-induced long-term potentiation (LTP).

Specifications

Chemical Name or Material 1-Methyl-2,5-bis[[[(1 S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl](3-phenylpropyl)amino]carbonyl]pyridinium iodide
CAS 1206480-93-4
Quantity 10 mg
Target Cytokine Compounds
Molecular Formula C44H60IN5O4
Purity 98%
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