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Tocris Bioscience™ EM12-SO2F
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Catalog No. 785210
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10 mg
Catalog No. Quantity
78-521-0 10 mg
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Catalog No. 78-521-0

Supplier: Tocris Bioscience™ 7852/10

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Description

Potent covalent inhibitor of Cereblon

EM12-SO2F is a potent covalent Cereblon (CRBN) inhibitor (IC50 = 0.88 nM). Binds to a histidine residue (His353) in the IMiD binding pocket of CRBN and blocks the recruitment of its substrates. EM12-SO2F prevents Lenalidomide (Cat. No. 6305)-induced degradation of the zinc finger transcription factor IKZF1 in MOLT4 cells. It complements CRBN based PROTAC and genetic methods to validate CRBN-mediated degradation.

Specifications

Chemical Name or Material 2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-3-oxo-1H-isoindole-5-sulfonyl fluoride
CAS 2803819-61-4
Quantity 10 mg
Target CRBN
Molecular Formula C13H11FN2O5S
Purity 95%
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