MilliporeSigma™ MultiScreen™ 96-Well Assay Plates

Provide tools to perform high-throughput studies of ADME processes—the investigation of the adsorption, distribution, metabolism, and excretion of potential drugs

Catalog Number	Mfr. No.	Color	Material	For Use With (Application)
MAIPN4550	MilliporeSigma™ MAIPN4550	Clear	ABS Plastic	Avidin biotin linkages, DNA-binding proteins, protein binding, PAMPA
MPC4NTR10	MilliporeSigma™ MPC4NTR10	Clear	Styrene	Permeability studies
MSSACCEPT0R	MilliporeSigma™ MSSACCEPT0R	White	PTFE	Permeability and PAMPA assays
MAIPNTR10	MilliporeSigma™ MAIPNTR10	Clear	ABS Plastic	PAMPA
MATRNPS50	MilliporeSigma™ MATRNPS50	Clear	Styrene	PAMPA

Description

Versatile separation system combines a microplate with Millipore's membrane filtration to simplify and optimize drug discovery techniques, biochemical assays, and traditional sample preparation.

• Use with a vacuum manifold, automated liquid-handling system, or microplate scintillation counter—entire assays can be performed on one plate
• Membrane-to-plate seal ensures no reagent crosstalk and limited optical crosstalk Underdrain support structure allows liquid volumes to be maintained for incubation times of up to 21 days
• Also ensures quantitative filtrate transfer to a receiver plate placed in bottom of manifold

Choice of filter materials

• For high protein binding applications, use plates with Immobilon™-P PVDF or mixed cellulose esters For high nucleic acid binding, use plates with mixed cellulose esters, glass fiber, or positively charged DEAE membranes For charged biomolecule separations, choose from positively charged DEAE or negatively charged phosphocellulose membranes
• For low biomolecule binding, use plates with hydrophilic Durapore™ PVDF, Biopore™ PTFE, or polycarbonate membranes
• For assays that require solvent resistance, use plates with hydrophilic PTFE membranes

Each microporous membrane interacts distinctly with different proteins or biomolecules; therefore, it may be necessary to test different membrane types for each assay.

†Includes lid, filter plate, and receiver plate.
‡Includes extended centrifugal cover, filter plate, and receiver plate.
††Consists of a 96-place holder and a 96-well receiver plate preloaded with Microcon YM-10 filter units.

Specifications

• Sterility: Non-sterile