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Invitrogen™ Emerin Recombinant Rabbit Monoclonal Antibody (10Y5K9)
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Catalog No. PIMA535459
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PIMA535459 100 μL
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Catalog No. PIMA535459 Supplier Invitrogen™ Supplier No. MA535459
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Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: RERPMYGRDS AYQSITHYRP VSASRSSLDL SYYPTSSSTS FMSSSSSSSS WLTRRAIRPE NRAPGAGLGQ DRQVPLWGQL LLFLVFVIVL FFIYHFMQAE EGNPF.

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Emerin
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 10Y5K9
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.05% BSA and 0.02% sodium azide; pH 7.3
Gene Emd
Gene Accession No. O08579, P50402, Q63190
Gene Alias AW550900; EDMD; EMD; Emerin; LEM domain containing 5; LEMD5; STA
Gene Symbols Emd
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13726, 2010, 25437
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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