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Invitrogen™ Emerin Monoclonal Antibody (CL0203)
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Catalog No. PIMA531328
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100 μL
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Catalog No. Quantity
PIMA531328 100 μL
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Catalog No. PIMA531328 Supplier Invitrogen™ Supplier No. MA531328
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Description

Mouse Monoclonal Antibody

Immunogen sequence: ASSYSFSDLN STRGDADMYD LPKKEDALLY QSKGYNDDYY EESYFTTRTY GEPESAGPSR AVRQSVTSFP DADAFHHQVH DDDLLSSSEE ECKDRERPMY GRDSACQSIT HY Highest antigen sequence indentity to the following orthologs: Mouse - 71%, Rat - 73%.

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Emerin
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone CL0203
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Emd
Gene Accession No. P50402
Gene Alias AW550900; EDMD; EMD; Emerin; LEM domain containing 5; LEMD5; STA
Gene Symbols Emd
Host Species Mouse
Immunogen Recombinant protein fragment of Human EMD (Product #RP-91926)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2010
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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