Invitrogen™ Emerin Monoclonal Antibody (MANEM1(5D10))

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA518076

Catalog No. PIMA518076

Description

This antibody does not cross-react with mouse samples. This target has a predicted molecular weight of 29 kDa.

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.

Specifications

• Antigen: Emerin
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% sodium azide
• Gene Accession No.: P50402
• Gene Symbols: Emd
• Immunogen: Recombinant Human Emerin aa 1-188.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rabbit
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot, Immunocytochemistry, Western Blot
• Clone: MANEM1(5D10)
• Conjugate: Unconjugated
• Gene: Emd
• Gene Alias: AW550900; EDMD; EMD; Emerin; LEM domain containing 5; LEMD5; STA
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 100328755, 2010
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid