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Tocris Bioscience™ EN6
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Catalog No. 747410
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Quantity:
10 mg
50 mg
Catalog No. Quantity
74-741-0 10 mg
74-745-0 50 mg
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Catalog No. 74-741-0

Supplier: Tocris Bioscience™ 7474/10

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Description

H+ ATPase activator; activates autophagy; inactivates mTORC1 signaling

EN6 is an activator of lysosomal vacuolar H+ ATPase (v-ATPase). EN6 covalently binds to the catalytic subunit of v-ATPase leading to increased acidification of lysosomes, inactivation of mTORC1 signaling and activation of autophagy in vivo. EN6 triggers entosis and promotes clearance of TDP43 protein aggregates in vitro.

Specifications

Chemical Name or Material N-[4-Fluoro-3-[(1-oxo-2-propen-1-yl)amino]phenyl]-1-(2-fluorophenyl)-1 H-pyrazole-4-carboxamide
CAS 1808714-73-9
Quantity 10 mg
Target H+-ATPase Inhibitors
Molecular Formula C19H14F2N4O2
Purity 0.98
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