Invitrogen™ Endostatin Polyclonal Antibody

Catalog No.	Quantity
PIPA595896	100 μL

Catalog No. PIPA595896 Supplier Invitrogen™ Supplier No. PA595896

Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse lung; Cellular Location: extracellular matrix, extracellular space Immunogen sequence: PGLPGNQGPP GPKGAKGEVG PPGPPGQFPF DFLQLEAEMK GEKGDRGDAG QKGERGEPGG GGFFGSSLPG PPGPPGPRGY PGIPGPKGES IRGQPGPPGP Q.

Endostatin is able to avoke non-uniform response for proliferation, cell mount and migration of entothelial cells, which different endostatin binding characteristic, leads to the assumption that endostatin effect is strongly dependent from endothelial cell type. Furthermore endostatin inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells. The local delivery of endostatin seems to specifically affect tumor-associated microvessels by reduction of the vessel density, diameter and functionality. Tumor cell migration and invasion was greatly reduced in the endostatin treated animals. Endostatin is non-toxic and does not induce aquired drug resistance and has therefor become a potent new therapy strategy in solid neoplasias. This therapy appears to have a high potential not only for the treatment of gliomas, the most common brain tumors, but also in other tumors. The ability of endostatin to inhibit neoangiogenesis is mediated, at least in part, by Zn^+2 binding and elastase processing. Widespread endostatin expression was found in elactic fibers in vessel walls and in some other basement membrane zones. Endostatin is released by neurons to accumulate in amyloid plaques in Alzheimer's disease.

Specifications

• Antigen: Endostatin
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: COL18A1
• Gene Accession No.: P39061
• Gene Alias: antiangiogenic agent; Col18a1; Collagen alpha-1(XVIII) chain; collagen type XVIII alpha 1 chain; collagen, type XVIII, alpha 1; endostatin; FLJ27325; FLJ34914; KNO; KNO1; KS; MGC74745; multi-functional protein MFP; NC1; Non-collagenous domain 1; procollagen, type XVIII, alpha 1
• Gene Symbols: COL18A1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human COL18A1 (NP_0850592).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12822
• Target Species: Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov