Invitrogen™ Endothelin 3 Monoclonal Antibody (OTI3E10)

Catalog No.	Quantity
PIMA527028	100 μL

Catalog No. PIMA527028 Supplier Invitrogen™ Supplier No. MA527028

Description

Mouse Monoclonal Antibody

Endothelin 3 Monoclonal Antibody for IHC (P)

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

Specifications

• Antigen: Endothelin 3
• Applications: Immunohistochemistry (Paraffin)
• Classification: Monoclonal
• Clone: OTI3E10
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: EDN3
• Gene Accession No.: P14138
• Gene Alias: 114CH19; EDN3; endothelin 3; endothelin-3; ET 3; Et3; ET-3; HSCR4; lethal spotting; ls; MGC15067; MGC61498; PPET3; Preproendothelin 3; preproendothelin-3; preproET-3; RGD1564825; RP4-614C15.1; tmgc48; WS4B
• Gene Symbols: EDN3
• Host Species: Mouse
• Immunogen: Human recombinant protein fragment corresponding to amino acids 17-238 of EDN3 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1908
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1