Invitrogen™ Endothelin 3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106860

Catalog No. PIPA5106860

Description

Antibody detects endogenous levels of total EDN3.

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

Specifications

• Antigen: Endothelin 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EDN3
• Gene Alias: 114CH19; EDN3; endothelin 3; endothelin-3; ET 3; Et3; ET-3; HSCR4; lethal spotting; ls; MGC15067; MGC61498; PPET3; Preproendothelin 3; preproendothelin-3; preproET-3; RGD1564825; RP4-614C15.1; tmgc48; WS4B
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13616, 1908, 366270
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P13207, P14138, P48299
• Gene Symbols: EDN3
• Immunogen: A synthesized peptide derived from human EDN3(Accession P14138), corresponding to amino acid residues A186-G236.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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