Endothelin 3 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5119887

Catalog No. PIPA5119887

Description

Positive Control: Raji cell lysate, 293 cell lysate, MCF-7 cell lysate, SW480 cell lysate, MG-63, rat placenta tissue, human placenta tissue, mouse placenta tissue. Subcellular Location: Secreted.

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.

Specifications

• Antigen: Endothelin 3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EDN3
• Gene Alias: 114CH19; EDN3; endothelin 3; endothelin-3; ET 3; Et3; ET-3; HSCR4; lethal spotting; ls; MGC15067; MGC61498; PPET3; Preproendothelin 3; preproendothelin-3; preproET-3; RGD1564825; RP4-614C15.1; tmgc48; WS4B
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13616, 1908, 366270
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: P13207, P14138, P48299
• Gene Symbols: EDN3
• Immunogen: Synthetic peptide within human Endothelin 3 aa 80-130
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov