Invitrogen™ ENO1 Monoclonal Antibody (NSE-P1)

Catalog No.	Quantity
PIMA517627	200 μg

Catalog No. PIMA517627 Supplier Invitrogen™ Supplier No. MA517627

Description

Mouse Monoclonal Antibody

MA5-17627 targets ENO1 in ELISA, IHC, and WB applications and shows reactivity with Human samples. The MA5-17627 immunogen is enolase of human origin.

Enolase (2-phosphogly-cerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the dehydration and conversion of 2-phosphoglycerate to phosphoenolpyruvate. It comprises three distinct subunits, alpha, beta and gamma. Non Neuronal Enolase(ENO1) is an isoform of mammalian enolase and is composed of 2 alpha subunits. The gene for ENO1 also encodes a shorter monomeric structural lens protein, tau-crystallin. Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.Used as a diagnostic marker for many tumors and, in the heterodimeric form, alpha/gamma, as a marker for hypoxic brain injury after cardiac arrest. Also marker for endometriosis. Antibodies against alpha-enolase are present in sera from patients with cancer-associated retinopathy syndrome (CAR), a progressive blinding disease which occurs in the presence of systemic tumor growth, primarily small-cell carcinoma of the lung and other malignancies. Is identified as an autoantigen in Hashimoto encephalopathy (HE) a rare autoimmune disease associated with Hashimoto thyroiditis (HT). HT is a disorder in which destructive processes overcome the potential capacity of thyroid replacement leading to hypothyroidism.

Specifications

• Antigen: ENO1
• Applications: ELISA, Immunohistochemistry, Western Blot
• Classification: Monoclonal
• Clone: NSE-P1
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: ENO1
• Gene Accession No.: P06733
• Gene Alias: 0610008I15; 2-phospho-D-glycerate hydrolase; 2-phospho-D-glycerate hydro-lyase; AL022784; alpha enolase; alpha enolase like 1; alpha-enolase; alpha-enolase; c-myc promoter-binding protein-1; c-Myc promoter binding protein; C-myc promoter-binding protein; Eno1; Eno-1; ENO1L1; enoa; Enolase 1; enolase 1, (alpha); enolase 1, alpha non-neuron; enolase-alpha; epididymis secretory protein Li 17; HEL-S-17; MBP-1; MBPB1; MPB1; MPB-1; MYC promoter-binding protein 1; NNE; Non-neural enolase; phosphopyruvate hydratase; Plasminogen-binding protein; PPH; tau-crystallin
• Gene Symbols: ENO1
• Host Species: Mouse
• Immunogen: Enolase of human origin.
• Purification Method: Protein G
• Quantity: 200 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2023
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ