Invitrogen™ ENPP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120818

Catalog No. PIPA5120818

Description

Positive test controls include: HepG2, A-549, Mouse kidney. The target is usually found in the following locations: Secreted. Immunogen sequence: DLGCTCDDKV EPKNKLDELN KRLHTKGSTE ERHLLYGRPA VLYRTRYDIL YHTDFESGYS EIFLMPLWTS YTVSKQAEVS SVPDHLTSCV RPDVRVSPSF SQNCLAYKND KQMSYGFLFP PYLSSSPEAK YDAFLVTNMV PMYPAFKRVW NYFQRVLVKK YASERNGVNV ISGPIFDYDY DGLHDTEDKI KQYVEGSSIP VPTHYYSIIT SCLDFTQPAD KCDGPLSVSS FILPHRPDNE ESCNSSEDES KWVEELMKMH TARVRDIEHL TSLDFFRKTS RSYPEILTLK TYLHTYESEI.

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified.

Specifications

• Antigen: ENPP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ENPP2
• Gene Alias: ATX; ATX-X; autotaxin; AutotaxinATX; autotaxin-t; ectonucleotide pyrophosphatase/phosphodiesterase 2; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; Enpp2; Extracellular lysophospholipase D; FLJ26803; lysoPLD; NPP2; Npps2; PD-IALPHA; PDNP2; phosphodiesterase I/nucleotide pyrophosphatase 2; phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin); plasma lysophospholipase D
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18606, 5168
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.01 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q13822, Q9R1E6
• Gene Symbols: ENPP2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 564-863 of human ENPP2 (NP_001035181.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov