Invitrogen™ ENSA Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105254

Catalog No. PIPA5105254

Description

Antibody detects endogenous levels of total ENSA.

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

Specifications

• Antigen: ENSA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ENSA
• Gene Alias: 1700020C18Rik; 2610007F17Rik; AI451924; Alpha-endosulfine; ARPP-19e; endosulfine alpha; endosulfine-alpha variant 1; endosulfine-alpha variant 3; ENSA
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2029, 56205, 60334
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O43768, P60840, P60841
• Gene Symbols: ENSA
• Immunogen: A synthesized peptide derived from human ENSA(Accession O43768), corresponding to amino acid residues Y41-L91.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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