Invitrogen™ Enterovirus 71 3D Monoclonal Antibody (4)

Catalog No.	Quantity
PIMA535903	100 μL

Catalog No. PIMA535903

Supplier: Invitrogen™ MA535903

Description

Mouse Monoclonal Antibody

Enterovirus 71 3D Monoclonal Antibody for Western Blot, ICC/IF, IP

EV71 is a positive-sense single-stranded RNA virus of the Picornaviridae family. It is known to cause hand, foot, and mouth disease and various neurological pathological conditions, such as aseptic meningitis and ataxia. EV71 is shown to utilize host UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1) to enhance viral replication and virulence. It forms replication complexes (RCs) on cellular membranes that contain a mix of host and viral proteins to facilitate viral replication. During infection viral RNA replication occurs on the cytoplasmic surfaces of single-membrane vesicles derived from the endoplasmic reticulum, and the membranes can serve to accelerate RC assembly during positive-strand genomic RNA replication. It has been shown that 3D polymerase, an RNA-dependent RNA polymerase that is encoded in the P3 viral genome region, plays a key role in EVA71 replication. Neural progenitor cells are shown to be prone to EV71 infection and that these stem cells can support the active replication of this virus.

Specifications

• Antigen: Enterovirus 71 3D
• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 4
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 20% glycerol and no preservative; pH 7
• Gene Alias: Enterovirus
• Host Species: Mouse
• Immunogen: The immunogen used to generate this antibody corresponds to EV71 3D.
• Purification Method: Protein G
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Virus
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1