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EP3 Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS1876R

Catalog No. 50-198-4254


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Description

Description

CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and haematopoietic stem cells. CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of CD172a to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates. Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs.
Specifications

Specifications

EP3
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
PTGER3
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
5733
PTGER3
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P43115
BOS_3434; EP3; Ep3 receptor; EP3e; EP3-I; EP3-II; EP3-III; EP3-IV; EP3-VI; MGC141828; MGC141829; MGC27302; PGE receptor EP3 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; PGE2-R; Pgerep3; pr; prostaglandin E receotor EP3 subtype 3 isoform; prostaglandin E receptor 3; prostaglandin E receptor 3 (subtype EP3); prostaglandin E receptor EP3 subtype; Prostaglandin E2 receptor EP3 subtype; prostaglandin receptor (PGE-2); Prostanoid EP3 receptor; PTGER3; Ptgerep3; Rep3; rEP3a; rEP3b
KLH conjugated synthetic peptide derived from human EP3.
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
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