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Invitrogen™ EPCR Monoclonal Antibody (RCR-252)
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Catalog No. PIMA533375
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100 μg
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Catalog No. Quantity
PIMA533375 100 μg
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Catalog No. PIMA533375 Supplier Invitrogen™ Supplier No. MA533375
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Description

Rat Monoclonal Antibody

Product is supplied at 1 mL (100 μL/mL). Application Notes: Flow cytometry- This antibody stains the extracellular domain of human EPCR. RE-1 cells were used as a positive control and N1 cells were used as a negative control. Western blot - A non-reduced sample treatment was used. The observed band size is 50 kDa. Functional Assay: This antiboyd functions as blocking antbody. It ablates APC binding to EPCR and blocks APC-mediated signaling. The antibody was functionally tested by pretreatment of cells with 10-25 μg/mL RCR-252. Positive control: RE-1 (rat 3Y1 fibroblasts stably transfected with human EPCR); Negative control: N1 cells.

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
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Specifications

Antigen EPCR
Applications Flow Cytometry, Functional Assay, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone RCR-252
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and no preservative
Gene Procr
Gene Accession No. Q9UNN8
Gene Alias Activated protein C receptor; AI325044; APC receptor; bA42O4.2; CCCA; CCD41; CD antigen CD201; CD201; CD201 antigen; cell cycle, centrosome-associated protein; centrocyclin; Centrosomal protein CCD41; endothelial cell protein C receptor; Endothelial protein C receptor; Epcr; PROCR; protein C receptor; protein C receptor, endothelial
Gene Symbols Procr
Host Species Rat
Immunogen Human EPCR-positive RE-1 cells.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10544
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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