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Invitrogen™ EphA2 Recombinant Human Monoclonal Antibody (1C1)
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Catalog No. PIMA547953
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200 μg
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Catalog No. Quantity
PIMA547953 200 μg
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Catalog No. PIMA547953 Supplier Invitrogen™ Supplier No. MA547953
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Description

Human Recombinant Monoclonal Antibody

Specificity: 1C1 binds specifically to the amino-termianal LBD (ligand-binding domain) region of the EphA2 ectodomain (IgG1 KD ~0.8 nM; Fab KD ~140 nM) and not to other related human Eph receptors such as EphA1, EphA2, and EphA4, or any EphB receptor family members.

EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
TRUSTED_SUSTAINABILITY

Specifications

Antigen EphA2
Applications ELISA, Flow Cytometry, Functional Assay, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone 1C1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene EPHA2
Gene Accession No. P29317
Gene Alias ARCC2; AW545284; CTPA; CTPP1; CTRCT6; Eck; EPH receptor A2; Epha2; ephrin receptor EphA2; Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; I79_019726; Myk2; Sek2; Sek-2; soluble EPHA2 variant 1; tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; tyrosine-protein kinase receptor SEK-2
Gene Symbols EPHA2
Host Species Human
Immunogen 1C1 was isolated after screening of a non-immunized human Fab phage library. Selection was based on the ability to bind soluble human recombinant EphA2 (residues 183-510). The Fab was subsequently converted to full length human IgG1.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1969
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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