Invitrogen™ EphB1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5109688

Catalog No. PIPA5109688

Description

Immunogen sequence: EPENSVACKA CPAGTFKASQ EAEGCSHCPS NSRSPAEASP ICTCRTGYYR ADFDPPEVAC TSVPSGPRNV ISIVNETSII LEWHPPRETG GRDDVTYNII CKKCRADRRS CSRCDDNVEF VPRQLGLTEC RVSISSLWAH TPYTFDIQAI NGVSSKSPFP PQHVSVNITT NQAAPSTVPI MHQVSATMRS ITLSWPQPEQ PNGIILDYEI RYYEKEHNEF NSSMARSQTN TARIDGLRPG M.

EPHB1 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. ephB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. ephB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cellcell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.

Specifications

• Antigen: EphB1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EPHB1
• Gene Alias: 9330129L11; AW488255; C130099E04Rik; Cek6; EK6; ELK; Elkh; ELK-related protein tyrosine kinase; ENSMUSG00000074119; Eph receptor B1; Eph receptor B2 (ELK-related protein tyrosine kinase); eph tyrosine kinase 2; EPHB1; Ephb2; EPH-like kinase 6; Ephrin type-B receptor 1; EPHT2; Epth2; Erk; Hek6; NET; Neuronally-expressed EPH-related tyrosine kinase; soluble EPHB1 variant 1; tyrosine-protein kinase receptor EPH-2
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2047, 270190
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.25 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P54762, Q8CBF3
• Gene Symbols: EPHB1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 260-500 of human EPHB1 (NP_004432.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG