Invitrogen™ Ephb1 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547736

Catalog No. PIPA547736

Description

In direct ELISAs, less than 5% cross-reactivity with recombinant mouse (rm) EphA3, rmEphA4, rmEphB2, rmEphB3, rmEphB4, and rmEphB6 is observed, less than 1% cross-reactivity with recombinant human (rh) EphA1, rhEphA5, rmEphA7, rmEphA8, and recombinant rat EphA5 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

EPHB1 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. EphB1 and other ephB family members are type 1 membrane spanning proteins, comprised of immunoglobulin, fibronectin type III, and cysteine rich subdomains in the ecto domain, and the single uninterrupted cytoplasmic tyrosine kinase domain upstream of a carboxyterminal sterile alpha motif (SAM) domain. ephB family proteins bind ephrins of the B class, ligands that are also transmembrane spanning proteins capable of transmitting signals. ephB1 is expressed predominantly in developing neural structures in embryos, and in vascular epithelium of kidney, and other tissues. Upon binding to alternatively oligomerized ephrin B1, ephB1 signals regulation of cell attachment and cellcell assembly. Members of this protein family are implicated in neuronal and vascular cell targeting.

Specifications

• Antigen: Ephb1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EPHB1
• Gene Alias: 9330129L11; AW488255; C130099E04Rik; Cek6; EK6; ELK; Elkh; ELK-related protein tyrosine kinase; ENSMUSG00000074119; Eph receptor B1; Eph receptor B2 (ELK-related protein tyrosine kinase); eph tyrosine kinase 2; EPHB1; Ephb2; EPH-like kinase 6; Ephrin type-B receptor 1; EPHT2; Epth2; Erk; Hek6; NET; Neuronally-expressed EPH-related tyrosine kinase; soluble EPHB1 variant 1; tyrosine-protein kinase receptor EPH-2
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 24338
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Flow Cytometry, Immunohistochemistry, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P09759
• Gene Symbols: EPHB1
• Immunogen: Mouse myeloma cell line NS0-derived recombinant rat EphB1 Met18-Gln538.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG