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Invitrogen™ EphB4 Polyclonal Antibody
Goat Polyclonal Antibody
Supplier: Invitrogen™ PA547013
Description
In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse (rm) EphB6 and rmEphA3 is observed and less than 1% cross-reactivity with rmEphA2, rmEphA4, rmEphA6, rmEphA7, rmEphA8, rmEphB2, and rmEphB3 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.
EPHB4 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EphB4 binds to ephrin-B2 and plays an essential role in vascular development.
Specifications
EphB4 | |
Polyclonal | |
Unconjugated | |
EPHB4 | |
AI042935; Developmental kinase 2; EPH receptor B4; Ephb4; ephrin receptor EphB4; ephrin type-B receptor 4; Hepatoma transmembrane kinase; HTK; Mdk2; mDK-2; MYK1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; TYRO11; Tyrosine kinase MYK-1; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase TYRO11 | |
Goat | |
Antigen affinity chromatography | |
RUO | |
13846, 2050 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Flow Cytometry, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry | |
0.2 mg/mL | |
PBS with 5% trehalose and No Preservative | |
P54760, P54761 | |
EPHB4 | |
Mouse myeloma cell line NS0-derived recombinant mouse EphB4 Leu16-Ala539. | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
Safety and Handling
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