Invitrogen™ EphB4 Polyclonal Antibody

Catalog No.	Quantity
PIPA547013	100 μg

Catalog No. PIPA547013 Supplier Invitrogen™ Supplier No. PA547013

Description

Goat Polyclonal Antibody

In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse (rm) EphB6 and rmEphA3 is observed and less than 1% cross-reactivity with rmEphA2, rmEphA4, rmEphA6, rmEphA7, rmEphA8, rmEphB2, and rmEphB3 is observed. Reconstitute at 0.2 mg/mL in sterile PBS.

EPHB4 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

Specifications

• Antigen: EphB4
• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative; pH 7.4
• Gene: EPHB4
• Gene Accession No.: P54760, P54761
• Gene Alias: AI042935; Developmental kinase 2; EPH receptor B4; Ephb4; ephrin receptor EphB4; ephrin type-B receptor 4; Hepatoma transmembrane kinase; HTK; Mdk2; mDK-2; MYK1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; TYRO11; Tyrosine kinase MYK-1; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase TYRO11
• Gene Symbols: EPHB4
• Host Species: Goat
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse EphB4 Leu16-Ala539.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 13846, 2050
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov