Invitrogen™ Ephrin B (Pan) Monoclonal Antibody (2D3E9)

Catalog No.	Quantity
37-810-0	100 μg

Catalog No. 37-810-0 Supplier Invitrogen™ Supplier No. 378100

Description

Mouse Monoclonal Antibody

Ephrin B (Pan) Monoclonal Antibody for Western Blot, ICC/IF, ELISA, IP

Ephrin B genes, including Ephrin B1, B2, and B3, encode membrane-bound ligands that interact with Eph receptors, particularly EphB1 through EphB6. These ligands are crucial for various developmental processes, notably in the cardiovascular and nervous systems. Ephrin B2 is prominently expressed in arterial endothelial cells, while its receptor EphB4 is found in venous endothelial cells, highlighting a key distinction early in vascular development. Disruption of these genes can lead to significant vascular remodeling failures during embryogenesis. Ephrin-Eph receptor signaling involves the binding of ephrin molecules to their receptors on adjacent cells, initiating heterodimerization and receptor autophosphorylation, followed by recruitment of signaling clusters. This signaling is essential for various physiological and pathological functions, including heart development and function, as well as the formation and maintenance of the glomerular tuft in kidneys.

Specifications

• Antigen: Ephrin B (Pan)
• Applications: ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 2D3E9
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene: EFNB3
• Gene Accession No.: O73612, P52799, P98172, Q15768
• Gene Alias: CEK5 ligand; CEK5 receptor ligand; CEK5-L; CEL5-L; CFND; CFNS; EFB1; EFL3; EFL-3; EFL6; EFNB1; EFNB3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; ephrin B1; Ephrin B3; EphrinB1; ephrin-B1; Ephrin-B1 C-terminal fragment; Ephrin-B1 CTF; Ephrin-B1 ICD; Ephrin-B1 intracellular domain; Ephrin-B1 precursor; Epl2; EPLG2; EPLG8; kinase ephrin-B1; Lerk2; LERK-2; LERK8; Stimulated by retinoic acid gene 1 protein; Stra1; STRA1 protein; transmembrane ligand
• Gene Symbols: EFNB1, EFNB2, EFNB3
• Host Species: Mouse
• Immunogen: Synthetic peptide derived from the ephrin-B sequence.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1947, 1948, 1949, 395625, 395896
• Target Species: Human, Chicken
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ