Invitrogen™ Ephrin B1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589907

Catalog No. PIPA589907

Description

Immunogen sequence: TVLLLKLRKR HRKHTQQRAA ALSLSTLASP KGGSGTAGTE PSDIIIPLRT TENNYCPHYE KVSGDYGHPV YIVQEMPPQS PANIYYKV; Positive Samples: Mouse brain; Cellular Location: Membrane, Single-pass type I membrane protein.

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

Specifications

• Antigen: Ephrin B1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: EFNB1
• Gene Alias: CEK5 ligand; CEK5 receptor ligand; CEK5-L; CEL5-L; CFND; CFNS; EFB1; EFL3; EFL-3; EFL6; EFNB1; EFNB3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; ephrin B1; Ephrin B3; EphrinB1; ephrin-B1; Ephrin-B1 C-terminal fragment; Ephrin-B1 CTF; Ephrin-B1 ICD; Ephrin-B1 intracellular domain; Ephrin-B1 precursor; Epl2; EPLG2; EPLG8; kinase ephrin-B1; Lerk2; LERK-2; LERK8; Stimulated by retinoic acid gene 1 protein; Stra1; STRA1 protein; transmembrane ligand
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13641
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.96 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P52795
• Gene Symbols: EFNB1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 259-346 of human EFNB1 (NP_0044201).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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