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Invitrogen™ Epiandrosterone Polyclonal Antibody
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Catalog No. PIPA175128
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PIPA175128 1 mg
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Catalog No. PIPA175128 Supplier Invitrogen™ Supplier No. PA175128
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Description

Sheep Polyclonal Antibody

Working Concentration: 1.25 μg/mL. Sensitivity: 10 ng/mL Epiandrosterone produces 74% inhibition in a competitive ELISA employing Epiandrosterone polyclonal antibody.

Epiandrosterone is a dehydroepiandrosterone metabolite and a precursor of testosterone and estradiol with hypolipidemic and anabolic property. Epiandrosterone, a potential neurosteroid, appears to bind to the gamma-aminobutyric acid (GABA)/benzodiazepine-receptor complex (GABA-RC), acting as a negative non-competitive modulator of GABA-RC as well as signal through the N-methyl-D-aspartate receptor. In addition this agent inhibits the pentose phosphate pathway (PPP) thereby dilating blood vessels pre-contracted by partial depolarization. Also, epiandrosterone inhibits the synthesis of thromboxane A2 in activated platelets, reduces plasma plasminogen activator inhibitor type 1 and tissue plasminogen activator antigen, increases serum levels of insulin-like growth factor 1 and increases cyclic guanosine monophosphate and nitric oxide synthesis. These effects may improve circulation in the microvasculature. [National Center for Biotechnology Information. PubChem Compound Database; CID=441302].
TRUSTED_SUSTAINABILITY

Specifications

Antigen Epiandrosterone
Applications ELISA
Classification Polyclonal
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene Alias 3beta-androsterone; 3Beta-hydroxy-5alpha-androstan-17-one; 5alpha-androstan-3beta-ol-17-one; C19H30O2; Epiandrosterone; Isoandrosterone; Trans-Androsterone
Host Species Sheep
Immunogen Epiandrosterone(17)-BTG.
Purification Method Purified
Quantity 1 mg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Chemical
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
Target Molecule Chemical
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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