Invitrogen™ Epiregulin Polyclonal Antibody

Catalog No.	Quantity
PIPA546969	100 μg

Catalog No. PIPA546969 Supplier Invitrogen™ Supplier No. PA546969

Description

Goat Polyclonal Antibody

In direct ELISAs and Western blots, approximately 50% cross-reactivity with recombinant mouse Epiregulin is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.

Specifications

• Antigen: Epiregulin
• Applications: ELISA, Neutralization, Western Blot, Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5% trehalose and No Preservative
• Gene: Ereg
• Gene Accession No.: O14944
• Gene Alias: Ep; Epiregulin; EPR; ER; EREG; Proepiregulin
• Gene Symbols: Ereg
• Host Species: Goat
• Immunogen: E. coli-derived recombinant human Epiregulin Val63-Leu108.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2069
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG

Safety and Handling

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