Invitrogen™ Epiregulin Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547057

Catalog No. PIPA547057

Description

In direct ELISAs, approximately 40% cross-reactivity with recombinant human Epiregulin is observed. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Epiregulin is an EGF-related growth factor that binds specifically to EGFR (ErbB1) and ErbB4, but not ErbB2 or ErbB3. It is expressed mainly in the placenta and peripheral blood leukocytes, as well as in certain carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and vascular smooth muscle cells. It also inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence.

Specifications

• Antigen: Epiregulin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ereg
• Gene Alias: Ep; Epiregulin; EPR; ER; EREG; Proepiregulin
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 13874
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Neutralization, Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative; pH 7.4
• Gene Accession No.: Q61521
• Gene Symbols: Ereg
• Immunogen: E. coli-derived recombinant mouse Epiregulin Val56-Leu101.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov