Invitrogen™ Epo Monoclonal Antibody (148436)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA523874

Catalog No. PIMA523874

Description

Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Erythropoietin (EPO) protein is a growth factor essential for the survival, proliferation, and differentiation of erythroid precursors. EPO is not responsible for early commitment to the lineage, and instead induces the final maturation of partially differentiated erythroid cells and the production of red cell-specific proteins, such as hemoglobin. The EPO receptor (EPOR) is present in higher levels on precursor cells, and expression diminishes with cell maturation.Hepatocytes are the main source of EPO in the fetus, followed by interstitial cells of the kidney after birth and through adulthood. EPO expression is upregulated during hypoxia, and low levels of transcription have also been detected in lung and brain tissue under these conditions. Recent data suggest that EPO may also play a role in the protection of neuronal tissue from damage and initiation of repair.

Specifications

• Antigen: Epo
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P07321
• Gene Symbols: EPO
• Immunogen: CHO-derived recombinant mouse Erythropoietin Ala27-Arg192.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Neutralization
• Clone: 148436
• Conjugate: Unconjugated
• Gene: EPO
• Gene Alias: EP; EPO; Epoetin; erythropoietin; MGC138142; MVCD2
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 13856
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized