Invitrogen™ EpoR Monoclonal Antibody (38409)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA523824

Catalog No. PIMA523824

Description

In direct ELISAs, no cross-reactivity with recombinant mouse Erythropoietin R is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

EpoR encodes the erythropoietin receptor, which belongs to the cytokine receptor family. When erythropoietin binds to this receptor, it activates the Jak2 tyrosine kinase, which in turn activates various intracellular pathways including Ras/MAP kinase, phosphatidylinositol 3-kinase, and STAT transcription factors. The stimulated erythropoietin receptor plays a role in the survival of erythroid cells. Defects in this gene may result in erythroleukemia and familial erythrocytosis. Dysregulation of this gene may also affect the growth of certain tumors. Multiple transcript variants are produced as a result of alternate splicing. Diseases associated with EPOR include Erythrocytosis, Familial, 1 and Erythroleukemia.

Specifications

• Antigen: EpoR
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P19235
• Gene Symbols: EPOR
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Erythropoietin R Pro26-Pro250.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry, Immunoprecipitation, Western Blot
• Clone: 38409
• Conjugate: Unconjugated
• Gene: EPOR
• Gene Alias: EPO R; EPOR; EPO-R; Erythropoietin receptor; pEpoR
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 2057
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized