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Invitrogen™ EPPK1 Polyclonal Antibody
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Catalog No. PIPA566913
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100 μL
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PIPA566913 100 μL
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Catalog No. PIPA566913 Supplier Invitrogen™ Supplier No. PA566913
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: STGRFKGCSVS LWDLLLSEYV GADKRRELVA LCRSGRAAAL RQVVSAVTTL VEAAERQPLQ ATFRGLRKQV SARDLFRAQL ISRKTLDEL Highest antigen sequence identity to the following orthologs - mouse 36%, rat 36%.

Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization.
TRUSTED_SUSTAINABILITY

Specifications

Antigen EPPK1
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene EPPK1
Gene Accession No. P58107
Gene Alias 450 kDa epidermal antigen; epidermal autoantigen 450K; EPIPL; EPIPL1; epiplakin; epiplakin 1; EPPK1
Gene Symbols EPPK1
Host Species Rabbit
Immunogen Recombinant Human EPPK1. Recombinant protein control fragment (Product #RP-107564).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 83481
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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