Tocris Bioscience EPPTB
Trace amine 1 (TA1) receptor antagonist/inverse agonist
Manufacturer: Tocris Bioscience 4518/50
DescriptionTrace amine 1 (TA1) receptor antagonist/inverse agonist; exhibits a higher potency at the mouse TA1 receptor than the rat and human TA1 receptors (IC50 values are 27.5, 4539 and 7487 nM, respectively). Blocks the TA1 receptor-mediated activation of an inwardly rectifying K+ current, which increases the firing frequency of dopamine (DA) neurons in the ventral tegmental area. Increases DA potency at the D2 receptor. Also displays inverse agonism, reducing basal cAMP levels in vitro (IC50 = 19 nM).
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|Target: Miscellaneous Compounds|
Safety and Handling
Recommended Storage : Store at 4°C
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