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  5. Tocris Bioscience™ EPZ 015666

Tocris Bioscience™ EPZ 015666
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Catalog No. 651625
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25 mg
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Catalog No. Quantity
65-162-5 25 mg
65-165 5 mg
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Catalog No. 65-162-5 Supplier Tocris Bioscience™ Supplier No. 6516/25
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Description

Potent and selective PRMT5 inhibitor

EPZ 015666 is a potent and selective protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50 = 22 nM, Ki = 5 nM). Displays selectivity for PRMT5 over a panel of 20 other protein methyltransferases. Exhibits dose-dependent antitumor effects in multiple mantle cell lymphoma (MCL) xenograft models. Orally bioavailable.

Specifications

Chemical Name or Material N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide
CAS 1616391-65-1
Quantity 25 mg
Molecular Formula C20H25N5O3
Formula Weight 383.44
Purity 98%
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