ERAS Mouse anti-Human, Clone: OTI3A3, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF503753

Catalog No. 50-166-2362

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The human ERAS gene was initially reported as a processed pseudogene (HRasp, Ha-Ras2), with several base substitutions in coding regions, but was more recently described as potentially encoding a functional human ERAS protein. The ERAS oncogene supports the tumorigenic growth of embryonic stem cells by producing a constitutively active Ras protein. ERAS protein has less than 50% amino acid identity with H-Ras, another member of Ras family but the key domains essential for Ras function are highly conserved. The protein also contains amino-acid residues identical to those present in active mutants of Ras and causes oncogenic transformation in NIH 3T3 cells. Human ERAS gene is localized in the chromosomal region Xp11.23.

Specifications

• Antigen: ERAS
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ERAS
• Gene Alias: HRAS2, HRASP
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 3266
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI3A3
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q7Z444
• Gene Symbols: ERAS
• Immunogen: Full length human recombit protein of human ERAS produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1