ERAS Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA571907

Catalog No. PIPA571907

Description

The human ERAS gene was initially reported as a processed pseudogene (HRasp, Ha-Ras2), with several base substitutions in coding regions, but was more recently described as potentially encoding a functional human ERAS protein. The ERAS oncogene supports the tumorigenic growth of embryonic stem cells by producing a constitutively active Ras protein. ERAS protein has less than 50% amino acid identity with H-Ras, another member of Ras family but the key domains essential for Ras function are highly conserved. The protein also contains amino-acid residues identical to those present in active mutants of Ras and causes oncogenic transformation in NIH 3T3 cells. Human ERAS gene is localized in the chromosomal region Xp11.23.

Specifications

• Antigen: ERAS
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ERAS
• Gene Alias: HRAS2; HRASP; E-Ras; GTPase ERas; embryonic stem cell-expressed Ras; small GTPase protein E-Ras; v-Ha-ras Harvey rat sarcoma viral oncogene homolog 2; v-Ha-ras Harvey rat sarcoma viral oncogene homolog pseudogene
• Host Species: Rabbit
• Purification Method: selective precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 3266
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 3.84 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: Q7Z444
• Gene Symbols: ERAS
• Immunogen: KLH conjugated synthetic peptide between 13-42 amino acids from the N-terminal region of human ERAS
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG