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ERBB2 Mouse anti-Human, Biotin, Clone: OTI1A12, liquid, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA700241

Encompass_Preferred

Catalog No. 50-167-7756


May include imposed supplier surcharges.
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Description

Description

ErbB2 (Her2/neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR (epidermal growth factor receptor) family that regulates biological responses such as cell growth, differentiation, and tissue development. ErbB2 has no ligand binding domain of its own and cannot bind growth factors. However, ErbB2 does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Autophosphorylation of tyrosine 1139 on ErbB2 allows binding of Grb2 and the Src SH2 domain, which allows activation of the Ras, Raf, ERK1/2 and JAK/STAT signaling pathways, respectively. Alternative splicing of ErbB2 results in several transcript variants, some encoding different isoforms and others that have not been fully characterized. In humans, the gene encoding ERBB2 is present on chromosome 17. Amplification and/or overexpression of the ErbB2 gene has been reported in ovarian tumors, breast, lung and skin cancer.
Specifications

Specifications

ERBB2
OTI1A12
Biotin
ERBB2
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Mouse
Affinity Chromatography
RUO
2064
-20° C, Avoid Freeze/Thaw Cycles
Liquid
Monoclonal
0.5 mg/mL
PBS with 10mg/ml BSA, 50% glycerol and 0.05% sodium azide
P04626
ERBB2
Full length human recombit protein of human ERBB2 produced in HEK293T cell.
50 μg
Primary
Human
Antibody
IgG1
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