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ERBB2 Mouse anti-Human, Clone: ERB2/776, Abnova™

Mouse monoclonal antibody raised against partial recombinant human ERBB2.

Manufacturer:  Abnova Corporation MAB13268

Catalog No. 89-934-109


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Description

Description

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq]

Specifications

Specifications

ERBB2
ERB2/776
Mouse monoclonal antibody raised against partial recombinant human ERBB2.
In 10mM PBS.
CD340/HER-2/HER-2/neu/HER2/NEU/NGL/TKR1
Mouse
IgG1, kappa
100 ug
Store at -20 to -80°C.
Aliquot to avoid repeated freezing and thawing.
Monoclonal
This monoclonal antibody is specific to ERBB2 and shows minimal cross-reaction with other members of the family.
Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
Unconjugated
Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
Liquid
ERBB2
Recombinant protein corresponding to intracellular domain of human ERBB2.
Protein A/G purification
RUO
Primary
2064
Human
SDS
Documents
Product Certifications
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