ERBB2 Mouse anti-Human, Clone: ERB2/776, Abnova™
Mouse monoclonal antibody raised against partial recombinant human ERBB2.
Manufacturer: Abnova Corporation MAB13267
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq]
|Mouse monoclonal antibody raised against partial recombinant human ERBB2.|
|In 10mM PBS (0.05% BSA, 0.05% sodium azide).|
|Store at 4°C.|
|This monoclonal antibody is specific to ERBB2 and shows minimal cross-reaction with other members of the family.|
|Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)|
|Flow Cytometry (0.5-1 ug/106 cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.|
|Recombinant protein corresponding to intracellular domain of human ERBB2.|
|Protein A/G purification|
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