ERBB2 Mouse anti-Human, Clone: ERB2/776, Abnova™

Catalog No.	Quantity
89-934-108	100 μg

Catalog No. 89-934-108 Supplier Abnova Corporation Supplier No. MAB13267

Description

Mouse monoclonal antibody raised against partial recombinant human ERBB2.

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq]

Specifications

• Antigen: ERBB2
• Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (PFA fixed)
• Classification: Monoclonal
• Clone: ERB2/776
• Conjugate: Unconjugated
• Description: Mouse monoclonal antibody raised against partial recombinant human ERBB2.
• Dilution: Flow Cytometry (0.5-1 ug/10⁶ cells in 0.1 mL) Immunofluorescence (0.5-1 ug/mL) Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In 10mM PBS (0.05% BSA, 0.05% sodium azide).
• Gene Alias: CD340/HER-2/HER-2/neu/HER2/NEU/NGL/TKR1
• Gene Symbols: ERBB2
• Host Species: Mouse
• Immunogen: Recombinant protein corresponding to intracellular domain of human ERBB2.
• Purification Method: Protein A/G purification
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2064
• Test Specificity: This monoclonal antibody is specific to ERBB2 and shows minimal cross-reaction with other members of the family.
• Target Species: Human
• Content And Storage: Store at 4°C.
• Form: Liquid
• Isotype: IgG1 κ