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ERBB2 Mouse anti-Human, Clone: SPM495, Abnova™

Catalog No. 89934110 Shop All Abnova Corporation Products
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89-934-110 50 μg
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Catalog No. 89-934-110 Supplier Abnova Corporation Supplier No. MAB12552

Item Discontinued This item has been discontinued by the supplier. Please to view product availability in your area.

Description

Mouse monoclonal antibody raised against human ERBB2.

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq]

Specifications

Antigen ERBB2
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Monoclonal
Clone SPM495
Conjugate Unconjugated
Description Mouse monoclonal antibody raised against human ERBB2.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL) Western Blot The optimal working dilution should be determined by the end user.
Formulation In 10mM PBS, pH 7.4 (BSA, sodium azide).
Gene Alias CD340/HER-2/HER-2/neu/HER2/NEU/NGL/TKR1
Gene Symbols ERBB2
Host Species Mouse
Immunogen A synthetic peptide corresponding to C-terminus region of human ERBB2.
Purification Method Protein G purification
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2064
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
Isotype IgG1 κ
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