Learn More
ERCC5/XPG Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Supplier: Bethyl Laboratories, Inc A301484A

Description
The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3′ incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.Specifications
ERCC5/XPG | |
Polyclonal | |
Unconjugated | |
ERCC5 | |
RP11-484I6.5, COFS3, ERCM2, UVDR, XPG, XPGC | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
2073 | |
4° C | |
Liquid |
Immunohistochemistry, Immunoprecipitation, Western Blot | |
0.2 mg/ml | |
TBS with 0.1% BSA and 0.09% sodium azide | |
P28715 | |
ERCC5 | |
Between 650 and 700 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.