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ERCC5/XPG Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501560507
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50-156-0507 100 μL
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Catalog No. 50-156-0507 Supplier Bethyl Laboratories, Inc Supplier No. A301484A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3′ incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.

Specifications

Antigen ERCC5/XPG
Applications Immunohistochemistry, Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.2 mg/ml
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene ERCC5
Gene Accession No. P28715
Gene Alias RP11-484I6.5, COFS3, ERCM2, UVDR, XPG, XPGC
Gene Symbols ERCC5
Host Species Rabbit
Immunogen Between 650 and 700
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2073
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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