Invitrogen™ ERCC8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521281

Catalog No. PIPA521281

Description

Recommended positive controls: Molt-4, C8D30, Rat2. Predicted reactivity: Mouse (91%), Rat (91%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a WD repeat protein, which interacts with Cockayne syndrome type B (CSB) protein and with p44 protein, a subunit of the RNA polymerase II transcription factor IIH. Mutations in this gene have been identified in patients with hereditary disease Cockayne syndrome (CS). CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes.

Specifications

• Antigen: ERCC8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ERCC8
• Gene Alias: 2410022P04Rik; 2810431L23Rik; 4631412O06Rik; B130065P18Rik; Ckn1; Cockayne syndrome 1 (classical); Cockayne syndrome 1 homolog; cockayne syndrome WD repeat protein CSA; Cockayne syndrome WD repeat protein CSA homolog; Cockayne syndrome WD-repeat protein CSA; CSA; DNA excision repair protein ERCC-8; ERCC excision repair 8, CSA ubiquitin ligase complex subunit; Ercc8; excision repair cross-complementation group 8; excision repair cross-complementing rodent repair deficiency complementation group 8; excision repair cross-complementing rodent repair deficiency, complementation group 8; excision repaiross-complementing rodent repair deficiency, complementation group 8; UVSS2
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 1161, 310071, 71991
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 5.39 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q13216, Q8CFD5
• Gene Symbols: ERCC8
• Immunogen: Recombinant fragment corresponding to a region within amino acids 1 and 194 of CSA (Uniprot ID#Q13216).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG