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ERG/KCNH2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984671
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50-198-4671 100 μL
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Catalog No. 50-198-4671 Supplier Bioss Supplier No. BS23703R
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Description

Rabbit Polyclonal Antibody

Human ether-a-go-go related gene (HERG) encodes the pore-forming alpha subunit of the delayed rectifier potassium channel IKr. There are two N-terminal splice variants of HERG include the full-length isoform 1 alpha and the shorter isoform 1 beta. Isoform 1 beta lacks the PAS motif and deactivates at a faster rate than isoform 1alpha. Residues within the C-terminal play a role in channel expression and channel gating, including voltage-dependent activation. HERG is expressed in the heart and is more abundantly expressed in the ventricles than in the atria. Mutations in the gene encoding HERG increase beat-to-beat variability and early after depolarization. These fluctuations facilitate the genesis and propagation of premature heartbeats associated with inheritable long QT syndrome type 2 and short QT syndrome type 1.

Specifications

Antigen ERG/KCNH2
Applications Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene KCNH2
Gene Accession No. Q12809
Gene Alias AI326795; BOS_4785; CERG; c-ERG; DERG; Eag homolog; eag related protein 1; eag-related protein 1; Erg; ERG1; ERG-1; ether-a-go-go related gene potassium channel 1; Ether-a-go-go-related gene potassium channel 1; ether-a-go-go-related potassium channel protein; ether-a-go-go-related protein 1; gp-erg; HERG; H-ERG; HERG1; HERG-1; KCNH2; Kv11.1; LQT; Lqt2; M-erg; Merg1; M-erg1; merg1a; merg1b; potassium channel protein ERG; potassium channel, voltage gated eag related subfamily H, member 2; Potassium voltage-gated channel subfamily H member 2; potassium voltage-gated channel, subfamily H (eag-related), member 2; ra-erg; RERG; r-ERG; SQT1; ventricular ERG K+ channel subunit; voltage-gated potassium channel 11.1; Voltage-gated potassium channel subunit Kv11.1; voltage-gated potassium channel, subfamily H, member 2
Gene Symbols KCNH2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human ERG/KCNH2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3757
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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