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Invitrogen™ ERH Polyclonal Antibody
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Catalog No. PIPA5109692
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100 μL
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PIPA5109692 100 μL
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Catalog No. PIPA5109692 Supplier Invitrogen™ Supplier No. PA5109692
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MSHTILLVQP TKRPEGRTYA DYESVNECME GVCKMYEEHL KRMNPNSPSI TYDISQLFDF IDDLADLSCL VYRADTQTYQ PYNKDWIKEK IYVLLRRQAQ QAGK.

The Enhancer of Rudimentary Homolog (ERH) is a highly conserved protein with significant roles in the regulation of gene expression and cell cycle control. Structurally, ERH forms homodimers, characterized by a crystal structure resolving at 2.0 A, which reveals its ability to bind specific protein regions via a hydrophobic groove. Functionally, ERH interacts with various cellular components, notably integrating into the Microprocessor complex where it facilitates microRNA maturation by binding with the N-terminus of DGCR8 at a 2:2 stoichiometry. This interaction underscores ERH's role in gene silencing, contributing to the biogenesis of small interfering RNAs (siRNAs). Additionally, ERH is implicated in transcriptional regulation and has been associated with DNA replication, suggesting its involvement in broader genomic functions. Despite its diverse roles, ERH operates in a plug-and-play manner, allowing its interaction with different cellular factors to fulfill pleiotropic functions across metazoans.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ERH
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.86 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene ERH
Gene Accession No. P84090
Gene Alias DROER; Enhancer of rudimentary homolog; enhancer of rudimentary homolog (Drosophila); Erh; Mer; Prei1; preimplantation protein 1
Gene Symbols ERH
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-104 of human ERH (NP_004441.1).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2079
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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