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Invitrogen™ ERH Polyclonal Antibody
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Catalog No. PIPA521388
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100 μL
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PIPA521388 100 μL
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Catalog No. PIPA521388 Supplier Invitrogen™ Supplier No. PA521388
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549, H1299, HCT116, mouse brain. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (99%), Xenopus laevis (100%), Pig (100%), Chicken (98%), Rhesus Monkey (100%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The Enhancer of Rudimentary Homolog (ERH) is a highly conserved protein with significant roles in the regulation of gene expression and cell cycle control. Structurally, ERH forms homodimers, characterized by a crystal structure resolving at 2.0 A, which reveals its ability to bind specific protein regions via a hydrophobic groove. Functionally, ERH interacts with various cellular components, notably integrating into the Microprocessor complex where it facilitates microRNA maturation by binding with the N-terminus of DGCR8 at a 2:2 stoichiometry. This interaction underscores ERH's role in gene silencing, contributing to the biogenesis of small interfering RNAs (siRNAs). Additionally, ERH is implicated in transcriptional regulation and has been associated with DNA replication, suggesting its involvement in broader genomic functions. Despite its diverse roles, ERH operates in a plug-and-play manner, allowing its interaction with different cellular factors to fulfill pleiotropic functions across metazoans.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ERH
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.79 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene ERH
Gene Accession No. P84089, P84090
Gene Alias DROER; Enhancer of rudimentary homolog; enhancer of rudimentary homolog (Drosophila); Erh; Mer; Prei1; preimplantation protein 1
Gene Symbols ERH
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human ERH. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 13877, 2079
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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