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Invitrogen™ ERI1 Monoclonal Antibody (OTI1B3)
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Catalog No. PIMA525827
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100 μL
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PIMA525827 100 μL
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Catalog No. PIMA525827 Supplier Invitrogen™ Supplier No. MA525827
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Description

Mouse Monoclonal Antibody

ERI1 Monoclonal Antibody for Western Blot, IHC (P)

RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ERI1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1B3
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ERI1
Gene Accession No. Q5FVR4, Q8IV48
Gene Alias 3 ' exoribonuclease; 3' exoribonuclease; 3110010F15Rik; 3'-5' exonuclease ERI1; 3'-5' exoribonuclease 1; 3'EXO; 3'HEXO; enhanced RNAi protein 1; enhanced RNAi three prime mRNA exonuclease homolog 1; ERI1; eri-1; Eri-1 homolog; exoribonuclease 1; HEXO; histone mRNA 3' end-specific exonuclease; histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; protei; protein 3'hExo; RGD1308378; Thex1; three prime histone mRNA exonuclease 1; three prime mRNA exonuclease 1
Gene Symbols ERI1
Host Species Mouse
Immunogen Full length human recombinant protein of ERI1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361159, 90459
Target Species Human, Rat, Monkey
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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