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ERI1 Mouse anti-Human, Non-human primate, Rat, Clone: OTI1B3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA525827

Catalog No. PIMA525827


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Description

Description

RNA exonuclease that binds to the 3 ft.-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2 ft. and 3 ft.-hydroxyl groups at the last nucleotide of the histone 3 ft.-end is required for efficient degradation of RNA substrates. Also able to degrade the 3 ft.-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5 ft.-ACCCA-3 ft. sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3 ft.-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
Specifications

Specifications

ERI1
Monoclonal
1.1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q5FVR4, Q8IV48
3′ exoribonuclease; 3′-5′ exonuclease ERI1; 3′-5′ exoribonuclease 1; Eri-1 homolog; enhanced RNAi three prime mRNA exonuclease homolog 1; histone mRNA 3′ end-specific exonuclease; histone mRNA 3′-end-specific exoribonuclease; histone mRNA 3′-exonuclease 1; protein 3′hExo; three prime histone mRNA exonuclease 1; three prime mRNA exonuclease 1
Mouse
IgG2b
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
361159, 699381, 90459
Immunohistochemistry (Paraffin), Western Blot
OTI1B3
Unconjugated
ERI1
Liquid
Eri1
Full length human recombit protein of ERI1 produced in HEK293T cell
Affinity Chromatography
RUO
Antibody
Monoclonal
Human, Non-human primate, Rat
Documents
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