ERI1 Mouse anti-Human, Non-human primate, Rat, Clone: OTI1B3, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA525827
DescriptionRNA exonuclease that binds to the 3 ft.-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2 ft. and 3 ft.-hydroxyl groups at the last nucleotide of the histone 3 ft.-end is required for efficient degradation of RNA substrates. Also able to degrade the 3 ft.-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5 ft.-ACCCA-3 ft. sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3 ft.-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|3′ exoribonuclease; 3′-5′ exonuclease ERI1; 3′-5′ exoribonuclease 1; Eri-1 homolog; enhanced RNAi three prime mRNA exonuclease homolog 1; histone mRNA 3′ end-specific exonuclease; histone mRNA 3′-end-specific exoribonuclease; histone mRNA 3′-exonuclease 1; protein 3′hExo; three prime histone mRNA exonuclease 1; three prime mRNA exonuclease 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|361159, 699381, 90459|
|Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of ERI1 produced in HEK293T cell|
|Human, Non-human primate, Rat|
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