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ERK1/2 Rabbit anti-Human, Mouse, Polyclonal, Proteintech
SDP

Catalog No. 501727008 Shop All Proteintech Group Inc Products
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50-172-7008 150 μL
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Catalog No. 50-172-7008 Supplier Proteintech Group Inc Supplier No. 112571AP150UL
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Description

Rabbit Polyclonal Antibody

This antibody can recognize both ERK1 and ERK2 with the molecular mass of 38-43 kDa.

MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. The p44/42 MAPK (Erk1/2) are members of mitogen-activated kinases (MAPKs) of serine/threonine protein kinases. Phospho ERK1/2 can be activated by a range of extracellular stimuli, such as mitogen, growth factors, neurotransmitters, chemokines, and cytokines, through receptor tyrosine kinases (RTK), G protein-coupled receptors (GPCRs), or protein kinase C (PKC). Upstream MEK1 and MEK2 activate p44 and p42 (phospho ERK1/2) through phosphorylation of activation loop residues Thr202/Tyr204 and Thr185/Tyr187, respectively. p44/42 (ERK1/2) are negatively regulated by a family of dual-specificity (Thr/Tyr) MAPK phosphatases, known as DUSPs or MKPs, along with MEK inhibitors, such as U0126 and PD98059.

Specifications

Antigen ERK1/2
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.22 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene MAPK1
Gene Accession No. P27361, P28482, P63085, Q63844
Gene Alias ERK, ERK 1, ERK1, ERK1/2, ERT2, HS44KDAP, HUMKER1A, Insulin stimulated MAP2 kinase, MAP kinase 1, MAP kinase 3, MAP kinase isoform p44, MAPK 1, MAPK 3, MAPK3, p44 ERK1, p44 MAPK, P44ERK1, P44MAPK, PRKM3
Gene Symbols MAPK1, MAPK3
Host Species Rabbit
Immunogen ERK1/2 Fusion Protein Ag1759
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26413, 26417, 5594, 5595
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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