MilliporeSigma™ ERK1/MAPK3, Rabbit, Unlabeled, Clone: UP-158-22-3-10,
Rabbit Monoclonal Antibody
Manufacturer: MilliporeSigma™ 05957I
DescriptionMitogen-activated protein kinase 3 (EC 220.127.116.11; UniProt P21708; also known as ERK-1, ERT2, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase 3, MAP kinase isoform p44, MAPK 3, Microtubule-associated protein 2 kinase, MNK1, p44-ERK1, p44-MAPK) is encoded by the Mapk3 (also known as Erk1, Prkm3) gene (Gene ID 50689) in rat species. ERK1 (a.k.a. MAPK 3) and ERK2 (a.k.a. MAPK 1 or MAPK 2) are related serine/threonine kinases of the Ras-Raf-MEK-ERK signaling pathway. ERK1/2 are activated by MEK1/2-catalyzed phosphorylation at their conserved Thr-Glu-Tyr (TEY) dual phosphorylation motif, first at the Tyr residue (human/rat ERK1 Tyr204/Tyr203, human/rat ERK2 Tyr187/Tyr183) and then at the Thr residue (human/rat ERK1 Thr202/Thr201, human/rat ERK2 Thr185/Thr181). ERK1/2 are proline-directed kinases that preferentially catalyze the phosphorylation of Pro-Xxx-Ser/Thr-Pro sequence motif in hundreds of cytoplasmic and nuclear substrates, including transcription factors such as Ets, Elk, and c-Fos. Besides this primary structure requirement, many ERK1/2 substrates possess a D-docking site and/or an F-docking site. A variety of scaffold proteins, including KSR1/2, IQGAP1, MP1, and -Arrestin1/2, also participate in the regulation of ERK1/2 MAP kinase cascade. Ras-Raf-MEK-ERK signaling activity is upregulated in about one-third of all human cancers, and targeted inhibition against components of this signaling pathway represents a popular anticancer strategy.
|Mapk3, Erk1, Prkm3|
|KLH-conjugated linear peptide corresponding to the C-terminal sequence of rat ERK-1 (MAPK 3).|
|Epigenetics & Nuclear Function|
|Human, Mouse, Rat|
|Please refer to lot specific datasheet.|
|Rabbit monoclonal antibody IgG hybridoma culture supernatant without preservatives.|
|Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.|
|Clone UP-158-22-3-10 recognizes a C-terminal epitope of MAPK 3 (ERK1). Immunogen sequence is not present in human MAPK3 spliced isoform 3 (ERK1b).|
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For Research Use Only. Not for use in diagnostic procedures.