Invitrogen™ ERK5 Recombinant Rabbit Monoclonal Antibody (5C1P5)

Catalog No.	Quantity
PIMA535422	100 μL

Catalog No. PIMA535422

Supplier: Invitrogen™ MA535422

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: LSKSQVEDPL PPVFSGTPKG SGAGYGVGFD LEEFLNQSFD MGVADGPQDG QADSASLSAS LLADWLEGHG MNPADIESLQ REIQMDSPML LADLPDLQDP.

MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK7 is activated by mitogen-activated protein kinase 5 (MAP2K5/MEK5) and is involved in downstream signaling processes of various receptors. In response to extracelluar signals, MAPK7 translocates to the cell nucleus where it regulates gene expression by phosphorylating and activating different transcription factors. Gene deletion of MAPK7 in mice results in defective blood vessel and cardiac development leading to embryonic lethality. MAPK7 has been shown to be critical for endothelial function and maintenance of blood vessel integrity. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. ERK5 is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver.

Specifications

• Antigen: ERK5
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 5C1P5
• Concentration: 0.8 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: MAPK7
• Gene Accession No.: P0C865, Q13164, Q9WVS8
• Gene Alias: Big MAP kinase 1; BMK1; BMK-1; BMK1 kinase; BNhp-1; BNhp1 kinase; ERK4; ERK5; ERK-5; Erk5-T; extracellular signal regulated kinase 5; extracellular signal-regulated kinase 5; extracellular-signal-regulated kinase 5; MAP kinase 7; MAPK 7; Mapk7; mitogen activated protein kinase 7; mitogen-activated protein kinase 7; PRKM7
• Gene Symbols: MAPK7
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 717-816 of human ERK5 (Q13164).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 114509, 23939, 5598
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG